TitlePopulation genomics of early events in the ecological differentiation of bacteria.
Publication TypeJournal Article
AuthorsB Shapiro J, Friedman J, Cordero OX, Preheim SP, Timberlake SC, Szabó G, Polz MF, Alm EJ
Date2012 Apr 06
KeywordsChromosomes, Bacterial, Ecosystem, Evolution, Molecular, Gene Flow, Gene Transfer, Horizontal, Genes, Bacterial, Genetic Variation, Genome, Bacterial, Models, Genetic, Molecular Sequence Data, Mutation, Oceans and Seas, Phylogeny, Polymorphism, Single Nucleotide, Recombination, Genetic, Seawater, Selection, Genetic, Vibrio

Genetic exchange is common among bacteria, but its effect on population diversity during ecological differentiation remains controversial. A fundamental question is whether advantageous mutations lead to selection of clonal genomes or, as in sexual eukaryotes, sweep through populations on their own. Here, we show that in two recently diverged populations of ocean bacteria, ecological differentiation has occurred akin to a sexual mechanism: A few genome regions have swept through subpopulations in a habitat-specific manner, accompanied by gradual separation of gene pools as evidenced by increased habitat specificity of the most recent recombinations. These findings reconcile previous, seemingly contradictory empirical observations of the genetic structure of bacterial populations and point to a more unified process of differentiation in bacteria and sexual eukaryotes than previously thought.

Alternate JournalScience
PubMed ID22491847
PubMed Central IDPMC3337212
Grant ListU54 GM088558 / GM / NIGMS NIH HHS / United States
U54 GM088558-02 / GM / NIGMS NIH HHS / United States
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