TitleTopological features of a gene co-expression network predict patterns of natural diversity in environmental response.
Publication TypeJournal Article
AuthorsDes Marais DL, Guerrero RF, Lasky JR, Scarpino SV
JournalProc Biol Sci
Date2017 Jun 14

Molecular interactions affect the evolution of complex traits. For instance, adaptation may be constrained by pleiotropic or epistatic effects, both of which can be reflected in the structure of molecular interaction networks. To date, empirical studies investigating the role of molecular interactions in phenotypic evolution have been idiosyncratic, offering no clear patterns. Here, we investigated the network topology of genes putatively involved in local adaptation to two abiotic stressors-drought and cold-in Arabidopsis thaliana Our findings suggest that the gene-interaction topologies for both cold and drought stress response are non-random, with genes that show genetic variation in drought expression response (eGxE) being significantly more peripheral and cold response genes being significantly more central than genes which do not show GxE. We suggest that the observed topologies reflect different constraints on the genetic pathways involved in environmental response. The approach presented here may inform predictive models linking genetic variation in molecular signalling networks with phenotypic variation, specifically traits involved in environmental response.

Alternate JournalProc. Biol. Sci.
PubMed ID28615505
PubMed Central IDPMC5474086
Research Lab
Des Marais Lab
Groups audience

More Information

  1. Des Marais Lab

    Banner Image
    Group user permission inheritance
    Inherit Permissions - inherited users in this group's subgroups will have the permissions as they do in this group and not the permissions of generic members of that subgroup.
    Parsons Laboratory
    Banner Position
    Above toolbar (stretched)
    Banner Text
    The Des Marais Lab
    Group user inheritance
    No - subgroups of this group won't inherit its users.
    Group visibility
    Public - accessible to all site users

    The primary focus of research in the Des Marais Lab is to understand the mechanisms of plant-environment interaction.

    We use tools from molecular, quantitative and population genetics to identify the physiological basis of plant response to environmental cues, and ask how these mechanisms constrain or facilitate plant breeding and evolutionary change.
    Learn more

    Group roles and permissions
    Use default roles and permissions
    Override default space options
    Space Blueprint