Publications

TitleTopological features of a gene co-expression network predict patterns of natural diversity in environmental response.
Publication TypeJournal Article
Year2017
AuthorsDes Marais DL, Guerrero RF, Lasky JR, Scarpino SV
JournalProc Biol Sci
Volume284
Issue1856
Date2017 Jun 14
ISSN1471-2954
Abstract

Molecular interactions affect the evolution of complex traits. For instance, adaptation may be constrained by pleiotropic or epistatic effects, both of which can be reflected in the structure of molecular interaction networks. To date, empirical studies investigating the role of molecular interactions in phenotypic evolution have been idiosyncratic, offering no clear patterns. Here, we investigated the network topology of genes putatively involved in local adaptation to two abiotic stressors-drought and cold-in Arabidopsis thaliana Our findings suggest that the gene-interaction topologies for both cold and drought stress response are non-random, with genes that show genetic variation in drought expression response (eGxE) being significantly more peripheral and cold response genes being significantly more central than genes which do not show GxE. We suggest that the observed topologies reflect different constraints on the genetic pathways involved in environmental response. The approach presented here may inform predictive models linking genetic variation in molecular signalling networks with phenotypic variation, specifically traits involved in environmental response.

DOI10.1098/rspb.2017.0914
Alternate JournalProc. Biol. Sci.
PubMed ID28615505
PubMed Central IDPMC5474086
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    The primary focus of research in the Des Marais Lab is to understand the mechanisms of plant-environment interaction.

    We use tools from molecular, quantitative and population genetics to identify the physiological basis of plant response to environmental cues, and ask how these mechanisms constrain or facilitate plant breeding and evolutionary change.
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